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diagnosis differential sle erythematosus management systemic algorithm causes hematology signs symptoms syndrome testing activation autoantibodies autoinflammatory comparison dil disease e1
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... ) Blood (75%): Anemia ... Leucopenia/lymphopenia, Thrombocytopenia ... symptoms #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... #differential #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Schistocytes, thrombocytopenia ... cardiac valve, vasculitis ... Diagnosis #Algorithm #workup ... #hematology #testing
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... • Immunologic Workup ... • Immunologic Workup ... Lupusreference #druginduced ... #table #rheumatology
Causes of Pericarditis - Differential Diagnosis Algorithm Viral: • Coxsackie • Echovirus • Adenovirus • Epstein-Barr virus
• Rheumatoid arthritis ... • Systemic lupus ... spondyloarthropathies • Vasculitis ... Metabolic: • Uremia ... Algorithm #Causes #Cardiology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ANCA-associated vasculitis ... Non-autoimmune rheumatologic ... • Mesenteric vasculitis ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis #Rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
recurrent fevers, vasculitis ... Abnormalities: macrocytic anemia ... , thrombocytopenia ... • giant cell arteritis ... Autoinflammatory #Somatic #rheumatology
Causes of Pericardial Effusion - Differential Diagnosis Infectious: • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus • Bacterial: Mycobacterium
Non-Infectious: • Rheumatologic ... SLE, Rheumatoid Arthritis ... Mediterranean Fever • Vasculitis ... • Metabolic: Uremia ... Diagnosis #Causes #cardiology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... SJIA], systemic lupus ... with leukopenia, anemia ... , and thrombocytopenia ... #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... the presence of anemia ... #laboratory #workup ... diagnosis #testing #Rheumatology
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