29 results
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
Algorithm for workup ... of thrombocytopenia ... TTP/HUS indicates ... thrombotic thrombocytopenic ... , Hematology 2012
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
distinction has HUGE treatment ... and first-line treatment ... Microangiopathy #thrombocytopenic ... HemolyticUremicSyndrome #HUS #thrombocytopenia ... Diagnosis #Table #Hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Treatment of Thrombotic ... Thrombocytopenic ... Thrombotic #Thrombocytopenic ... #rheumatology # ... hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... Diagnosis and Workup ... Refractory ITP, ... Diagnosis #Causes #Workup ... #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
inflammation • Thrombocytopenia ... Primary Causes: - Thrombocytopenia ... disease - DIC/TTP ... Defects: • DIC, TTP ... #rheumatology #
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
• Rheumatic disorders ... effect following treatment ... of ITP • Rebound ... following EtOH induced thrombocytopenia ... Algorithm #Causes #Hematology
PLATELETS Mnemonic for Causes of Thrombocytopenia

P - Platelet Disorders (DIC, ITP, TTP)
L - Leukemia, Lymphoma
A -
for Causes of Thrombocytopenia ... P - Platelet Disorders ... (DIC, ITP, TTP) ... Mnemonic #Acronym #Thrombocytopenia ... Differential #Diagnosis #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Schistocytes, thrombocytopenia ... - DIC, TTP, HELLP ... Consider RBC membrane disorder ... Diagnosis #Algorithm #workup ... #hematology #testing
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... • TMA’s (HUS/TTP ... Schistocytes - MAHA: TTP ... + Bleeding Treatment ... diagnosis #causes #treatment
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
leukemia in adults • Disorder ... Symptoms of anemia or thrombocytopenia ... transformation) Treatment ... with anemia or thrombocytopenia ... Leukemia #oncology #hematology