14 results
differential rheumatology oncology treatment classification hemophagocytic hlh lymphohistiocytosis algorithm ana anca anemia antibodies antibody antineutrophil antinuclear aplastic atopic atopy cd4
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... to Kidney: Anti-GBM ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
- Differential Diagnosis ... Brucellosis, Q fever, EBV ... Malignancy: - Hematologic ... the most common vasculitis ... #Differential #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Ferritin >1000 ng ... Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... of emergency, ICU ... #management #treatment
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANCA-Associated Vasculitis ... Renal-limited vasculitis ... + 90% • Anti-GBM ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
symptoms, unexplained hematologic ... extralymphatic tissues Diagnosis ... to 50% of PTLD cases ... Disorders #oncology #diagnosis ... #management #transplant
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... Differential Diagnosis ... #rheumatology #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... and petechiae Causes ... Parvovirus B19 - EBV ... Anemia #oncology #hematology ... #diagnosis #management
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... antibody, Anti-GBM ... usually low in anti-GBM ... Goodpasture's cause ... #management #treatment
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... tract, and often causes ... pain and GN Anti-GBM ... #Rheumatology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
Lymphocytopenia DIAGNOSTIC ... CRITERIA FOR ICL ... EBV. CMV. ... #diagnosis #hematology ... #Differential #Causes
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