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differential causes management algorithm cold comparison hemolytic hemophagocytic hlh lymphohistiocytosis lymphoma workup agglutinin aplastic autoimmune cd4 classification diffuse disease disorders
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g., HIV), EBV ... Differential Diagnosis ... • Other hematologic ... NonHodgkins #comparison #oncology ... #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... Infectious • EBV ... Biopsy • Hodgkin's ... Algorithm #Causes #Hematology ... #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... supraclavicular node • Anterior ... Weight loss • Anemia ... classification #hematology ... #oncology #management
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Autoimmune Hemolytic Anemia ... Autoimmune Hemolytic Anemia ... Autoimmune Hemolytic Anemia ... Mycoplasma, HIV, EBV ... #hematology #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... Parvovirus B19 - EBV ... Epstein-Barr virus (EBV ... #oncology #hematology ... #diagnosis #management
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... workup, including BM ... hemolysis, deficiency anemia ... #Algorithm #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... in bone marrow (BM ... under 2%, then BM ... #Algorithm #Diagnosis ... #Workup #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Ferritin >1000 ng ... Infections+++: Virus (EBV ... Hemopathies+++: Hodgkin ... biologics (CMV +++, EBV ... of emergency, ICU
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... changes), high MCV anemia ... When do you do a BM ... #Differential #Diagnosis ... Causes #Workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... - Mycoplasma, EBV ... disease #hemolytic #anemia ... #hematology #diagnosis
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