12 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver Injury ... > 20x normal - Acute ... normal - Infection (EBV ... #hepatology #LFTs ... transaminitis #differential
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatitis A/B/C/D/E, EBV ... Hemochromatosis, Wilson's disease ... HELLP, Celiac disease ... Diagnosis #hepatology ... Transaminitis #LFTs
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... C, A, E, B, D, EBV ... Sophia_Hayes_MD #Liver #Injury ... #Differential # ... #algorithm #hepatology
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
CK Levels Acute ... (COVID19, CMV/EBV ... Illness Myopathy (ICU ... renal injury, Strenuous ... #CK #differential
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... HBV, HCV, HEV, EBV ... specificity to elevated ... diagnosis #algorithm #hepatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated ... Platelet Count - Differential ... workup, including BM ... Vasculitides, IBD, Celiac disease ... Thrombocytosis #Platelets #Differential
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... specificity to elevated ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... Mild jaundice, Elevated ... and hemorrhage Acute ... #Pregnancy #hepatology ... hepatitis #comparison #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... Hyperbilirubinemia • Elevated ... - Mycoplasma, EBV ... younger pts) Differential ... hemolytic #anemia #hematology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... Presentation: Injury ... CSF pleocytosis, elevated ... Brucellosis - Dengue, EBV ... management #neurology #differential