13 results
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Purpura (TTP) Diagnosis ... admission to the ICU ... Thrombocytopenic #Purpura #management ... #treatment #rheumatology ... #hematology
Central line myth #2: location, location, location 

By far the best data we have to guide
have to guide management ... in 3027 adult ICU ... but the overall rates ... The rates of complication ... pubmed/26398070 #EBM
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... Unknown cause Treatment ... of emergency, ICU ... #management #treatment
COVID-19 - A Seattle Intensivist's One-Page Cheat-Sheet on COVID-19 v2.7 Updated March 26 2020

(v2.7) incorporating newer
COVID19 in the ICU ... data on mortality rate ... Epidemiology • Attack rate ... #Management #Summary ... : Marino's The ICU
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... Coxsackie, CMV, EBV ... Stills #Disease #diagnosis ... #management #treatment ... #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... opacities • Diagnosis ... Renal Failure Treatment ... organ dysfuxtion, ICU ... #management #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... start and stop dates ... non-essential drug/HDS treatments ... HBV, HCV, HEV, EBV ... #Algorithm #hepatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Toxic injury to BM ... Parvovirus B19 - EBV ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 

DIAGNOSTIC CRITERIA FOR ICL
 • Persistent CD4 T-cell lymphopenia
 •
CD4 Lymphopenia (ICL ... CRITERIA FOR ICL ... EBV. CMV. ... #Lymphopenia #ICL ... #diagnosis #hematology
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
include Crackles/Rales ... & Dry) is the treatment ... #algorithm #management ... #cardiology #treatment ... #criticalcare #icu