20 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... Treatment: • ... of emergency, ICU ... #management #treatment
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
and Treatment ... - MH/CCF/CWRU EM ... #Differential # ... Diagnosis #Treatment ... #Management
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... (COVID19, CMV/EBV ... Illness Myopathy (ICU ... #Elevated #CK #differential ... #diagnosis #rhabdomyolysis
COVID-19 - A Seattle Intensivist's One-Page Cheat-Sheet on COVID-19 v2.7 Updated March 26 2020

(v2.7) incorporating newer
COVID19 in the ICU ... data on mortality rate ... 31 • First US case ... #Management #Summary ... : Marino's The ICU
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 

DIAGNOSTIC CRITERIA FOR ICL
 • Persistent CD4 T-cell lymphopenia
 •
CD4 Lymphopenia (ICL ... CRITERIA FOR ICL ... EBV. CMV. ... #Lymphopenia #ICL ... #diagnosis #hematology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... Diaqnoses: • ... Coxsackie, CMV, EBV ... #management #treatment ... #rheumatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... start and stop dates ... non-essential drug/HDS treatments ... for alternative causes ... HBV, HCV, HEV, EBV
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... initiation • Differential ... Renal Failure Treatment ... organ dysfuxtion, ICU ... #management #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Toxic injury to BM ... and petechiae Causes ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
life-threatening Differential ... myasthenia Diagnosis ... : - Bedside: ice ... Myasthenia #Gravis #diagnosis ... #management #neurology