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differential nephrology acute aki algorithm injury kidney rheumatology creatine elevated hemophagocytic hepatology hepatorenal hlh hrs icl idiopathic kinase lymphocytopenia lymphohistiocytosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... osmolarity If cause ... ANCA, ANA, Anti-GBM ... Anti-ds-DNA, C3/C4 ... #nephrology #causes
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... (COVID19, CMV/EBV ... Illness Myopathy (ICU ... infarction, Acute renal ... #differential #diagnosis
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
DIAGNOSTIC ... chemotherapy) • Genetic syndromes ... EBV. CMV. ... #diagnosis #hematology ... #Differential #Causes
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
- Differential Diagnosis ... Abdominal Compartment Syndrome ... GN: ANCA, Anti-GBM ... , C3/C4, Other ... #nephrology #causes
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Differential Diagnosis ... : - ANCA-positive ... anti-ANCA ab, anti-GBM ... ab, ANA, C3, C4 ... #diagnosis #nephrology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... Drugs, Unknown cause ... of emergency, ICU
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... • Caused by splanchnic ... Exclude other AKI causes ... Norepinephrine (ICU ... #Hepatology #Nephrology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... affects the skin, neurologic ... tract, and often causes ... pain and GN Anti-GBM ... #Rheumatology
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