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Irritable Bowel Syndrome (IBS) - Pathophysiology, Diagnosis and Management Algorithm
Risk factors: Previous acute enteric infection, Female
Irritable Bowel ... inflammation, Abdominal ... HT3 antagonists, Rifaximin ... Pregabalin #IBS #Irritable
Irritable Bowel Syndrome (IBS) Management Algorithm
Step 1: Good communication, dietary and lifestyle advice
Abdominal Pain:
 • 1st
Irritable Bowel ... lifestyle advice Abdominal ... , eluxadoline, rifaximin
Irritable Bowel Syndrome (IBS) - Diagnosis and Management Summary
Diagnosis:
 • Use a positive diagnostic strategy with
Irritable Bowel ... Criteria - Recurrent abdominal ... • IBS-D: - Rifaximin ... EmoryGastroHep #IBS #Irritable
IBS-D Pharmacotherapy

Loperamide
Rifaximin
Eluxadoline
Alosetron
Antispasmodics
Tricyclic antidepressants
SSRIs

#IBSD #IBS #Diarrhea #Irritable #Bowel #Syndrome #pharmacology #table #comparison #management #treatment
Loperamide Rifaximin ... IBS #Diarrhea #Irritable
Irritable Bowel Syndrome (IBS) Treatment Algorithm

IBS-Constipation:
 • Constipation: Osmotic laxatives
 • Abdominal pain: Antispasmodics

IBS-Diarrhea:
 • Diarrhea:
Irritable Bowel ... laxatives • Abdominal ... sequestrant • Abdominal ... Antispasmodics #Irritable
Irritable Bowel Syndrome (IBS) Treatment Options
Amitiza (Lubiprostone)
Antidepressants: Celexa, Wellbutrin, Prozac, Paxil, Nortriptyline, and Zoloft
Bentyl (Dicyclomine)
Creon
Ducolax
Imodium, Maalox,
Irritable Bowel ... Metoclopramide) Rifaxamin ... (Ranitidine) #irritable
Rifamycins - Antibiotics Class Overview

Include Rifampin, Rifaximin, Rifapentine, Rifabutin.

Mechanism: Inhibits bacterial DNA-dependent RNA polymerase (unique mechanism).
Include Rifampin, Rifaximin ... Rifaximin (PO) ... Rifamycins #Rifampin #Rifaximin
Irritable Bowel Syndrome (IBS) - Management
Global IBS Symptoms:
  - Limited trial low FODMAP diet
Irritable Bowel ... psychotherapies IBS-D: - Rifaximin ... EmoryGastroHep #IBS #Irritable
Management of Abdominal Distension and Bloating - Treatment Algorithm

Definitions
Pathophysiology
Organic/Pathologic Etiologies:
 • Small Intestinal Bowel Overgrowth (SIBO)
Management of Abdominal ... Interaction: • Irritable ... Functional Bloating • Abdomino-phrenic ... EmoryGastroHep #Abdominal
Diffuse Acute Abdominal Pain (<72 hours) - Differential Diagnostic Algorithm
Look for surgical abdomen
Upper quadrant: R/O cardiac,
Diffuse Acute Abdominal ... Perforation • Ruptured abdominal ... • Trauma • Irritable ... Diffuse #Acute #Abdominal