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diagnosis erythematosus hematology lupus management oncology sle comparison fungal galactomannan gout systemic aids aspergillus autoantibodies autoimmune biomarkers classification clues cppd
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... : Temperature rises ... Brucellosis Faget's Sign ... For every 1°F rise ... #Patterns #Differential
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Attempt if high risk ... Subacute-Acute: • Common: fever ... initiation • Differential ... Diagnosis: Infection
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... ) 30-45% Differential ... Other auto-immune, Infectious ... autoantibodies #signs ... #rheumatology
Pediatrics Sepsis Screening SIGNS OF INFECTION? • Fever (>38C) • Hypothermia (<36C) • Cough/chest pain/respiratory distress •
Pediatrics Sepsis ... OF INFECTION? ... • Fever (>38C) ... RISK MEDICAL CONDITIONS ... • Other high-risk
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
the face (many differential ... 9) Unexplained fever ... , when infection ... including in children (pediatric ... erythematosus #rheumatology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
invasive fungal infection ... surfaces - Infections ... useful in high risk ... BAL GM does not differentiate ... Fungal #Biomarkers #BetaDGlucan
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... • CT: Halo sign ... Pneumonia: • Risk ... AIDS #pulmonary #differential
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
surfaces, Albumin, Infections ... useful in high risk ... in BAL does not differentiate ... post-2010 almost never ... blood products #BetaDGlucan
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... Diagnose concomitant infection ... drug failure • Risk
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
diagnose concomitant infection ... inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... Gout #Comparison #rheumatology
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