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diagnosis management hematology rheumatology treatment aids chronic cll erythematosus hiv infectiousdiseases leukemia lupus lymphocytic sle systemic addisons adrenal autoantibodies autoimmune
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Attempt if high risk ... Subacute-Acute: • Common: fever ... Diagnosis: >3 symptoms ... initiation • Differential ... Diagnosis: Infection
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... : Temperature rises ... Brucellosis Faget's Sign ... For every 1°F rise ... #Patterns #Differential
Cytomegalovirus (CMV) in HIV-AIDS Patients Cytomegalovirus (CMV): double-stranded DNA virus, herpesvirus family. CMV infection: virus isolation or detection
CMV infection: virus ... or signs. ... Cardiovascular risk ... AIDS #diagnosis #differential ... #signs #symptoms
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... Other auto-immune, Infectious ... autoantibodies #signs ... #symptoms #mimickers ... #differential #
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Disorders: • Infection ... tuberculosis, fungal infections ... hypotension develops • Risk ... • Low-grade fever ... Reduced libido • Signs
Pediatrics Sepsis Screening SIGNS OF INFECTION? • Fever (>38C) • Hypothermia (<36C) • Cough/chest pain/respiratory distress •
Pediatrics Sepsis ... OF INFECTION? ... • Fever (>38C) ... RISK MEDICAL CONDITIONS ... • Other high-risk
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
→ fevers, night ... Complications: 1) Infection ... chemotherapy for low-risk ... Constitutional symptoms ... Lymphocytic #Leukemia #oncology
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... • CT: Halo sign ... Pneumonia: • Risk ... Constitutional symptoms
Spontaneous Bacterial Peritonitis DIAGNOSTICS Paracentesis: • Calculate absolute PMN count (total WBC x PMN %) • Correct
Treat if other signs ... (fever, abdominal ... small study, low-risk ... ß-blockers due to ↑ risk ... SBP • PPIs = ↑ risk
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Lymphadenopathy • Fevers ... weeks without infection ... Physical Exam/Signs ... diagnosis #workup #oncology
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