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rheumatology ana lupus management systemic patterns workup algorithm anca antibody antineutrophil arthritis arthropathies arthropathy autoantibodies bcnie bloodculture classification criteria disease
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus ( ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #rheumatology #diagnosis ... #differential
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... 40% Target: SS-A/Ro ... is clinically suspected ... #erythematosus ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... Kumfer @AnnKumfer #Antinuclear ... #rheumatology #diagnosis ... #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... erythematosus ... in drug-induced SLE ... Anti-Ro/SSA ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... #Diagnosis #Rheumatology
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
Joint Disorders - Differential ... Diagnosis Algorithm ... Erythematosus ( ... SLE), should have ... Joint #Disorders #msk
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Clinical Domains ... least 2 joints • Neurologic ... Highly specific antibodies ... Classification #Criteria #SLE ... #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... : Anti-Ro/SSA & ... ab • RF • Antinuclear ... salivary ducts Clinical ... phenomenon (16%) MSK
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
rheumatoid arthritis, SLE ... life-threatening Differential ... myasthenia Diagnosis ... immunologic assay - MuSK ... #management #neurology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... erythematosus ( ... SLE) - Antinuclear ... double-stranded DNA antibodies ... ANA and RF (if clinical
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