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management rheumatology antiphospholipid erythematosus neurology sle systemic anticoagulation aps cerebritis cns differential gravis guidelines hematology hypercoagulable inflammatory jointpain msk myasthenia
Antiphospholipid Syndrome (APS) APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid Syndrome ... ): • Lupus anticoagulant ... of 1 clinical event ... to be present Treatment ... #APS #diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... permeability Diagnosis ... (for secondary APS
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... lesions • Anti-Ro ... Differential Diagnosis ... Clinical Features ... Erythematosus #Diagnosis
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
- Differential Diagnosis ... Arthritis • Systemic Lupus ... Sicca) Syndrome ... Inflammatory #JointPain #MSK ... #Causes
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Clinical Picture ... Generalized fatigue - ALS ... myasthenia Diagnosis ... immunologic assay - MuSK ... Myasthenia #Gravis #diagnosis
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... renal failure Clinical ... symptoms are not caused ... skin (16-32%): lupus ... anterior/posterior MSK
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
(APLS) Testing ... - 1 or more clinical ... maternal chromosomal causes ... excluded Testing: • Lupus ... #diagnosis #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Antibodies: Anti-Ro ... Antibodies: • Anti-Ro ... salivary ducts Clinical ... phenomenon (16%) MSK ... Adenocarcinoma Treatment
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