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diagnosis hematology management differential algorithm deficiency pathophysiology signs leukemia mds myelodysplastic refeeding allergy antibiotics aplastic apml ascorbicacid b1 cancer chronic
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
• Vitamin E - Haemolytic ... anaemia, ataxia ... Wernicke-Korsakoff syndrome ... diagnosis #signs #symptoms ... #nutrition
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management Diagnosis - Caine Criteria (2 of
Encephalopathy - Acute ... Anorexia nervosa Treatment ... Encephalopathy • A prompt treatment ... can improve symptoms ... development of Korsakoff syndrome
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
diarrhoea, Short bowel syndrome ... dental fixatives, Treatment ... Haematological: Anaemia ... #riskfactors #symptoms ... #nutrition
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Injury: • Early acute ... hepatitis • Acute ... • Tumor lysis syndrome ... polyangiitis • Behçet's syndrome ... associated with any symptoms
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... transformation to acute ... only curative treatment ... #hematology #oncology
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
initiation of nutrition ... overload) Other Symptoms ... • Seizures • Hemolysis ... hyperparathyroidism Treatment ... #Nutrition #Differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... Treatment: ... • Improve the symptoms ... #oncology #hematology
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
Refeeding Syndrome ... - Little or no nutritional ... -DPG -> - hemolysis ... - anemia ... pathophysiology #symptoms
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
blood loss, Acute ... hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... Kawasaki, Nephrotic syndrome
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Platelet Disorders • Nutritional ... factor (GCSF) treatments ... marrow studies Treatment ... diagnosis #hematology #oncology
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