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rheumatology sle treatment blood classification druginduced erythematosus product reactions systemic vasculitis algorithm alkaline alp antinxp2 antinxp2dm cerebritis cns coagulation common
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... #rheumatology # ... cerebritis #diagnosis ... #management #treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Positive in 60-80% of cases ... 60-80% - Low ... Erythematosus #Diagnosis ... #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low ... Post-strep GN, Lupus ... #differential #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... 60-80% - Low ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
: • Low serum IgG ... and M panel Management ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... • Elevation of serum ... Hyophosphatasia #hepatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Labs/Diagnosis: ... factor level • Low ... (e.g. systemic lupus
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... contents into serum ... , Elevated Cr, Low ... Syndrome #TLS #diagnosis ... #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Prolonged PT/PTT • Low ... protein C and S Pathophysiology ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Blood Count - Low ... may be high or low ... • Increased Serum ... classification #hematology ... #oncology #management
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