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rheumatology differential hematology management classification erythematosus systemic comparison hodgkins leukemia lymphoma symptoms workup acidosis arthritis autoantibodies causes chronic cll druginduced
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... involvement 3% SLE-Related ... sclerosis, Still's disease ... Lupusreference #SLE ... autoantibodies #signs
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... erythematosus (ACLE ... erythematosus (SCLE ... La, anti-Jo-1, SCL
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... is rare in DIL, SCLE-DIL ... 40, F:M 9:1 • Clinical ... Evolution: Chronic disease ... #rheumatology #diagnosis
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Management Summary Clinical ... Signs: • hyperCalcemia ... demineralization) • Renal disease ... 48% (light chain ... #Management #oncology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Fever (50%), Depression ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Compensated polarized light ... joint • Systemic lupus ... (to support a diagnosis ... ANA and RF (if clinical ... laboratory #workup #diagnosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
• Clinical features ... Differential Diagnosis ... Malignancies (eg CML, ALL ... NonHodgkins #comparison #oncology ... #diagnosis #differential
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... Headaches, bone pain, fever ... splenomegaly), night ... Leukemia #Hematology #Oncology ... #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... such as systemic lupus ... Weight loss • Night ... purpura: strong sign ... vasculitis, and SLE
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Drenching night ... Physical Exam/Signs ... cells can indicate disease ... #workup #oncology
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