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diagnosis rheumatology classification algorithm antiarrhythmics differential management syndrome vasculitis workup adverseeffects ana anca antibody antineutrophil antinuclear antiphospholipid apls benefits biliary
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Post-strep GN, Lupus ... Normal Complement: IgA ... Purpura Anti-GBM antibodies
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... Anti-Ro/SSA ... #diagnosis #rheumatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary Cirrhosis ... 65 years PBC Pathophysiology ... intralobular bile ducts causes ... • Antithyroid antibodies ... diagnosis #workup #hepatology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
and Benefits in Lupus ... Hyperlipidemia, ↓ SSA-associated ... rare with ~100 cases ... Risks #Benefits #Lupus ... #pharmacology #
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
current) causing ↓SA ... Vaughan #Williams #Pharmacology ... Classification #Classes ... #pathophysiology ... #cardiology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... HIT: Heparin-PF4 antibodies ... Treat primary cause ... Coagulation #diagnosis #causes ... treatment #management #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... Hypocomplementemia • Can cause ... primary biliary cirrhosis ... Nephrogenic DI Hematologic ... lubricants • Pharmacologic
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... current) causing ↓SA ... Classification #Classes ... #pathophysiology ... #phases #cardiology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
maternal chromosomal causes ... excluded Testing: • Lupus ... Cardiolipin Antibody, IgA ... Glycoprotein 1 Antibody, IgA ... Algorithm #diagnosis #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Schonlein Purpura (IgA ... tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... C-ANCA) pattern: antibodies
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