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diagnosis antibody testing antibodies cytoplasmic nuclear vasculitis arthritis autoimmune classification comparison dermatologic dermatology gpa granulomatosis inflammatory joint management monoarthritis monoarticular
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Cytoplasmic Patterns ... Nuclear Patterns ... #differential # ... diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Testing - Nuclear Patterns ... Homogeneous pattern ... ) Speckled pattern ... #differential # ... diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
serial dilution, a pattern ... significant • Pattern ... : The ANA patterns ... Patterns and Associated ... #patterns #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Sjogren's Syndrome (SS ... @AnnKumfer #Antinuclear ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... Testing Cytoplasmic Patterns ... #Cytoplasmic #Patterns ... #differential # ... diagnosis #rheumatology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
: Subacute • Pattern ... : Subacute • Pattern ... or subacute • Pattern ... Insidious/slow • Pattern ... diagnosis #comparison #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... Tests: • CBC • LFT ... ) pattern: antibodies ... ) pattern: is usually ... #diagnosis #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... • Is there a pattern ... weeks) Can Be Caused ... asymmetric pattern ... #Joint #pain #Differential
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
coagulopathy) • CBC w differential ... pericardial effusion) • PFTs ... Goodpasture's cause ... • IF staining patterns ... Renal #Syndromes #differential
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
can appear as an ... GPA causes disease ... reticularis Differential ... with a certain pattern ... rash #diagnosis #rheumatology
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