364 results
Diabetes Combination Tablets - Estimated A1c Lowering 
Metformin + DPP4 
• Janumet (metformin + sitagliptin) 
•
Metformin + SGLT2 ... dapagliflozin) Dpp4 + SGLT2 ... Tablets #Oral #DM2
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors ... Action: Inhibits SGLT2 ... mL/minute/1.73 m2 ... EricsMedicalLectures/featured #SGLT2 ... Pharmacology #Summary #DM2
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
-4 inhibitors SGLT2 ... endocrinology #dm2
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
SGLT2 Inhibitors ... SGLT2 inhibitors ... /ambcarerx #SGLT2 ... #Medications #DM2
Metabolic Acidosis with Anion Gap - KILU Mnemonic

K - Ketoacidosis
	• DKA
		- With normal glucose, ask if
glucose, ask if on SGLT2 ... ketoacidosis in SGLT2 ... inhibitors and SGLT2 ... Acidosis #diagnosis #differential
Severity of Aortic Stenosis in Adults 
Current ACC/AHA guidelines recommend cut-off values for Doppler-echocardiographic measurements of
area (AVA) <1.0 cm2 ... surface area <0.6 cm2 ... /m2, mean gradient ... common problem in clinical ... combination of an AVA <1 cm2
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Decrease #Diagnosis #DM2 ... #Differential
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Action, Effects, Clinical ... Acetazolamide, others SGLT2
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD
EMPA-REG OUTCOME - Empagliflozin lowered CV events
Selected Clinical ... Trials of SGLT2 ... mcclaffertyMD #SGLT2
Terry's Nails

Proximal paleness extending halfway up the nail, often eliminating the lunula. Darker distal band. Seen
cirrhosis, CHF, DM2 ... #PhysicalExam #Clinical