13 results
Diabetes Pathophysiology and Medication Targets

The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... hyperglycemia in type 2 diabetes ... commonly used diabetes ... /ambcarerx #Diabetes ... #Drug #Endocrinology
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... Agents Subclass, Drug ... Tolvaptan #Diuretics ... #Medications #Pharmacology ... summary #table #nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
(treatment of diabetic ... syndrome (mimics loop diuretic ... mimics thiazide diuretic ... Conn's, Liddle's), Drugs ... differential #diagnosis #nephrology
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
class of anti-diabetic ... medications, with ... are similar to diuretics ... #Pharmacology #Medications ... #DM2 #Diabetes
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Altitude sickness • Diuretic ... • Nephrogenic diabetes ... Lithium-induced nephrogenic diabetes ... DDAVP) • Central diabetes ... #Medications #Table
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Correction of diabetic ... renal disease Drugs ... : - Loop diuretics ... #differential #medications ... #drugs #pharmacology
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Euglycemic Diabetic ... Inhibitors Increasing Indications ... Significant Adverse Drug ... level < 200 mg/dL Pathophysiology ... #Euglycemic #Diabetic
Causes of Hypomagnesemia
 • Redistribution: IV glucose, Correction of diabetic ketoacidosis, IV hyperalimentation, Refeeding after starvation,
Correction of diabetic ... Saline or osmotic diuresis ... renal disease • Drugs ... : Loop diuretics ... differential #diagnosis #nephrology
Compelling and Possible Contraindications to Antihypertensive Drugs
Diuretics (thiazides)
 - Gout
 - Metabolic syndrome, Glucose intolerance, Pregnancy,
Antihypertensive Drugs ... Diuretics (thiazides ... hyperkalemia (ACEI, ARB, diabetes ... failure - Co-medication ... antihypertensive #medications
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Ketoacidosis: Diabetic ... Drugs II. ... Potassium-sparing diuretics ... anti-inflammatory drugs ... diagnosis #causes #nephrology