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diagnosis transaminitis acute causes chronic dili gastroenterology hbv hepatitisb aclf chemistry cirrhosis drug druginduced failure hepatocellular hepbv idiosyncratic indications induced
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... Injury Differential ... #Injury #Differential ... #LFTs #hepatitis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... HSV • Toxic: Alcohol ... #Injury #Differential ... Causes #Acute #algorithm ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... hepatitis • Drugs ... • Others #LFTs ... #Hepatology #LiverEnzymes
Alcoholic Hepatitis - Management Algorithm 1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... - Management Algorithm ... #Hepatitis #Management ... #Algorithm #treatment ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... #differential # ... gastroenterology #algorithm ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... • Autoimmune hepatitis ... #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... ALT Ratios: • Alcoholic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Alcoholic Hepatitis - Summary Overview - Epidemiology - Pathophysiology - Clinical Features - Labs - Diagnosis - Differential Diagnosis - Treatment Sarah Onorato @sonorato11 #Alcoholic
Alcoholic Hepatitis ... Diagnosis - Treatment ... #Hepatitis #hepatology ... #diagnosis #algorithm ... #management
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