11 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... twitter.com/AmyChung #AntiCoagulation ... #Pharmacology #Pathophysiology ... Mechanisms #DOAC #Hematology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
Over-anticoagulation ... hemorrhage, while under-coagulation ... #pharmacology #treatment ... decisionaid #cardiology #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Kidney Failure Coagulation ... #ACLF #Acute #Chronic ... Failure #Cirrhosis #Hepatology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology ... #anticoagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... protein C and S Pathophysiology ... + Bleeding Treatment ... diagnosis #causes #treatment ... #management #hematology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... treat the pts with chronic ... Hbe-Ag. anti-Hbe ... Diagnosis #Management #Treatment ... #Hepatology
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Pulmonary Thromboendarterectomy
Chronic Thromboembolic Pulmonary Hypertension
Definition: mean pulmonary-artery pressure > 25mmHg
Chronic Thromboembolic ... Thromboendarterectomy Chronic ... pulmonary embolism Pathophysiology ... Bypass Other Treatment ... Rarely performed Anticoagulation
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook

Clinical Presentation + Progression:
Perforation) Pathophysiology ... Spore ingestion → colonic ... • Flex-Sig: If ... despite appropriate treatment ... IDSA 2021 CDI Treatment
Acute-phase Reactants Synthesized in the Liver 
Positive acute-phase reactants (concentrations increase with acute inflammation)
 - Immune-related
Ceruloplasmin - Coagulation ... Serum amyloid A (SAA ... Liver #Synthesis #Hepatology ... #pathophysiology
Essential Thrombocythemia (ET)
ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
(ET) ET is a chronic ... PV, MDS, CML) Treatment ... • Treatment is ... Hydroxyurea + anticoagulation ... Thrombocythemia #ET #hematology