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Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... Identify Acute Liver ... than ALT • ALT ... : Specific to liver ... Cholestasis/Bile salts
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
than ALT • ALT ... Cholestasis/Bile salts ... • AST: ↑ • ALT ... - ALP > AST/ALT ... kidney, brain • ALT
Biliary Circulation
1) Bile produced in the liver
2) Bile stored in the gallbladder
3) Bile excreted into the
produced in the liver ... 5) 95% of bile salts ... Remaining 5% of bile salts ... Re-absorbed bile salts ... returned to the liver
Side Effects of the Neobladder - Pathophysiology
 • Hercalciuria → Kidney Stones
 • Bone Resorption →
Hyperphosphatemia • Salt ... Increased burden on liver
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Occurs in advanced liver ... hepatitis, or acute liver ... • Definitive: Liver ... - Salt and ... • Urgent liver
Approach to Undifferentiated Shock - OnePager Summary
Shock occurs when there is inadequate blood flow (CO) &
neuraxial anesthesia), Liver ... , Renal Losses(salt-wasting
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Hepatocellular Liver ... or Cholestatic Liver ... @AnnKumfer #Liver
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... kidney, brain ALT ... specific for the liver ... / ULN ALT) / (ALP ... SinaiBmoreIMRes #Liver
Features of Components of Liver Function Tests #Diagnosis #IM #GI #LFTs #Liver #Function #Tests #Locations #AlkPhos
Components of Liver ... #IM #GI #LFTs #Liver ... #AlkPhos #AST #ALT
Liver Function Tests (LFTs)
 - Aspartate aminotransferase (AST) 
 - Alanine aminotransferase (ALT) 
 - Alkaline
Liver Function Tests ... aminotransferase (ALT ... Prothrombin #Liver