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diagnosis differential management hepatology nephrology treatment causes clinical hyponatremia hepatitis laboratory sodium transaminitis criticalcare workup classification comparison function hbv hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum (ALT ... /ULN ALT) / (Alk ... than ALT • ALT ... transaminitis #LFTs
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... ALT elevation > ... Alk phos • ALT ... • R value = (ALT ... + ULN ALT) / (alkaline
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... kidney, brain ALT ... Alkaline Phosphatase, ALT ... ULN R Value = (ALT ... / ULN ALT) / (ALP
Liver Function Tests (LFTs) - Aspartate aminotransferase (AST) - Alanine aminotransferase (ALT) - Alkaline
Liver Function Tests ... (LFTs) - Aspartate ... aminotransferase (ALT ... Prothrombin #Liver ... Function #Tests #LFTs
Features of Components of Liver Function Tests #Diagnosis #IM #GI #LFTs #Liver #Function #Tests #Locations #AlkPhos
Components of Liver ... Diagnosis #IM #GI #LFTs ... #Liver #Function ... Locations #AlkPhos #AST ... #ALT #Ddxof
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... • Severe - ALT ... • Moderate - ALT ... Others • Mild - ALT ... Burak @kwburak #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... than ALT • ALT ... Cholestasis/Bile salts ... : ↑ • ALT: ↑ ... differential #diagnosis #algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Severe ALT > 15x ... HELLP Moderate ALT ... • Others Mild ALT ... • Others #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... /ALT compared with ... /ALT) Hepatocellular ... Diagnosis #hepatology #algorithm ... Transaminitis #LFTs
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... Tests - AST, ALT ... and ALT: • AST ... cytoplasmic (CAST) • ALT ... Pathophysiology #Diagnosis #LFTs
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