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diagnosis oncology differential hematology algorithm generalized mds pruritus secondary systemic aplastic clinical leukemia manifestations myelodysplasia primary syndromes treatment ulcerative ulcers
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... associated with myelodysplastic ... most frequent skin ... polymorphism • Satellite ... #diagnosis #dermatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Syndrome (MD) - ... old, ~10,000 new cases ... cytopenias (usually anemia ... #treatment #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... just beneath the skin ... that are caused ... Out Secondary Causes ... #hematology #oncology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... renal failure/uremia ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... #generalized #dermatology
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
Skin Ulcers by Etiology ... Mycosis fungoides (cutaneous ... • Sickle Cell Anemia ... Ulcers #ulcerative #skinrash ... #dermatology #Differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... • Hypocellular myelodysplastic ... #oncology #hematology ... #diagnosis #management
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... #generalized #dermatology ... Diagnosis #Algorithm #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... - infiltrates (anemia ... violaceous, nontender cutaneous ... • Tumor lysis syndrome ... CLL -> Invade Skin
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