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diagnosis hematology syndrome leukemia mds myelodysplastic product reactions algorithm anemia antimda5 antimda5dm antinxp2 antinxp2dm aplastic chronic classification cll coagulation dic
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... old, ~10,000 new cases ... only curative treatment ... #treatment #hematology ... #oncology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
ulcerations • Skin ... onset [33-74%] • Blood ... • Skin vasculopathies ... #rheumatology # ... dermatology #diagnosis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... for secondary causes ... glucocorticoid treatment ... symptoms (eg, skin ... Differential #diagnosis #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Causes: - Idiopathic ... multiforme - Dermatomyositis ... neutrophils in the blood ... Treatment: - Systemic ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Out Secondary Causes ... factor (GCSF) treatments ... Syndromes #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... result from low blood ... #hematology #diagnosis ... #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... + Bleeding Treatment ... Treat primary cause ... #treatment #management ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... Lymphocytosis: Absolute blood ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... and lower jaw Treatment ... SAPHO #Syndrome #Rheumatology ... #diagnosis #management ... #Dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... -> AML: Blast crises ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
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