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diagnosis dermatology differential sle symptoms antimda5 antimda5dm antinxp2 antinxp2dm autoimmune classification complications erythematosus management manifestations mucocutaneous myopathy myositis oncology papulosquamous
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... erythematosus #signs ... symptoms #diagnosis #rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... #rheumatology #
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... inflammation on skin ... Malar (butterfly) Rash ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... such as systemic lupus ... purpura: strong sign ... differential #diagnosis #rheumatology
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin ... Rash - Differential ... Auspitz sign, Koebner's ... soles • Discoid Lupus ... #causes
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... Causes: - Idiopathic ... multiforme - Dermatomyositis ... Leukocytoclastic vasculitis ... ’s syndrome - Lupus
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... purpura: Strong sign ... , mucositis • Rash ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... chest (in a V-sign ... shoulders (in a shawl sign ... Muscle atrophy may cause ... diagnosis #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... papules and Gottron sign ... ) • Shawl sign ... statins - probably caused
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