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diagnosis rheumatology differential dermatology sle symptoms erythematosus systemic autoimmune behcet classification complications dermatologic disease gpa granulomatosis joint management mucocutaneous myopathy
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Antiphospholipid-antibody syndrome ... • Vasculitis ... lesions • Discoid lupus
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... inflammation on skin ... Malar (butterfly) Rash ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... , Vasculitis, Purpura ... of hip (rare), Arthritis ... Demyelinating syndromes ... erythematosus #signs
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... lesions (9.4%) • Maculopapular ... rash (6.7%) • ... • Goodpasture syndrome ... • Giant cell arteritis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... mucositis - Rash ... • Cogan Syndrome ... such as systemic lupus ... purpura: strong sign
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... M > F Clinical Manifestations ... response to local skin ... test (this is a skin ... diagnosis #management #signs
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... Episcleritis Signs ... Leukocytoclastic vasculitis ... - Lupus - Leukemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
evidence of (fatigue, rash ... 3rd Decade Skin ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... Seizures • Strokes Skin
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... , mucositis • Rash ... vesicles, pustules, maculopapular ... • Behcet syndrome ... • Cogan syndrome
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... ) • Shawl sign ... • Nonerosive arthritis ... Extramuscular manifestations
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