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diagnosis rheumatology dermatology differential erythematosus lupus oncology syndrome systemic vasculitis antimda5 antimda5dm antinxp2 antinxp2dm autoimmune classification clinical cutaneous joint management
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... • SLE • Human ... infection • Lyme disease ... IBD • RA • SLE
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
most frequent skin ... appearing during the disease ... polymorphism • Satellite ... manifestations (dermatomyositis ... , SLE,...) 4
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... chest (in a V-sign ... ulcerations • Skin ... severity of the disease
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... pain (20%) Renal disease ... erythematosus #signs
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... evidence of (fatigue, rash ... 3rd Decade Skin ... , dermatomyositis ... Seizures • Strokes Skin
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... sudden onset of a rash ... - Rash: multiple ... Episcleritis Signs ... multiforme - Dermatomyositis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Purpura, ischemic skin ... - Affects the skin ... mucositis - Rash ... purpura: strong sign ... vasculitis, and SLE
Pediatrics Sepsis Screening SIGNS OF INFECTION? • Fever (>38C) • Hypothermia (<36C) • Cough/chest pain/respiratory distress •
Pediatrics Sepsis ... vomiting/diarrhea • Skin ... pain/swelling/rash ... neuromuscular disease ... <94%, mottled skin
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... , such as SLE, atherosclerotic ... purpura: Strong sign ... , mucositis • Rash ... cmpkx deposits skin
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... chest (in a V-sign ... shoulders (in a shawl sign ... had more severe disease
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