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diagnosis symptoms rheumatology differential lupus syndrome behcet classification clinical complications criteria cutaneous dermatology erythematosus extraarticular kawasaki management mucocutaneous myelodysplastic oncology
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
most frequent skin ... appearing during the disease ... polymorphism • Satellite ... dermatomyositis, SLE ... leukocytoclastic vasculitis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... inflammation on skin ... Livedo Reticularis, Vasculitis ... #pathophysiology ... #diagnosis #signs
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Purpura, ischemic skin ... - Skin, glomeruli ... mucositis - Rash ... purpura: strong sign ... , and SLE) • Urinalysis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... pain (20%) Renal disease ... erythematosus #signs
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... M > F Clinical Manifestations ... Oral aphthae : SLE ... • Arthritis: SLE ... diagnosis #management #signs
Kawasaki Disease: Clinical Findings Diagnostic Criteria - Fever and 4/5 of the following: • Conjunctivitis • Polymorphous
Kawasaki Disease ... • Polymorphous rash ... - Generalized Skin ... #Diagnosis #Pathophysiology ... #Vasculitis
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... blood vessels (vasculitis ... interstitial lung disease ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... , such as SLE, atherosclerotic ... purpura: Strong sign ... , mucositis • Rash ... : • Skin lesions
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