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differential comparison dermatology symptoms systemic vasculitis antibodies associations autoantibodies classification cold common diseases distribution erythematosus inflammatory lupus myopathies myopathy myositis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis (Scleroderma ... Multi-system autoimmune ... thickening Signs ... #SSc #rheumatology ... #diagnosis #signs
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Autoimmune diseases ... trigger - Direct skin ... Disorientation, vertigo Diagnostic ... #diagnosis #rheumatology ... #comparison #table
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
- Differential Diagnosis ... large numbers of stellate ... #Differential #Diagnosis ... #comparison #table ... #dermatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... microsomal) - Autoimmune ... Anti-Scl-70 - Scleroderma ... Associations #diseases #diagnosis ... #table #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Vasculitis, Purpura, Urticaria ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
heliotrope, shawl sign ... exclusion Necrotizing Autoimmune ... #differential #diagnosis ... #comparison #rheumatology ... #table
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... Vasculitis): - Urticaria ... Differential Diagnosis ... purpura: strong sign ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... purpura: Strong sign ... #Differential #Diagnosis ... #Rheumatology
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
associated with signs ... macerated areas with satellite ... Fleshy papules • Urticaria ... ; pruritis #dermatology ... #differential #diagnosis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... ) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... Myositis #Myopathy #rheumatology
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