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diagnosis differential symptoms arthritis classification dermatology erythematosus joint pain sle syndrome systemic algorithm arthritides causes conditions cryoglobulinemia extrarticular inflammatory management
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’ ... like rheumatoid arthritis ... (RA) or systemic ... lupus erythematosus ... Xeroderma (Dry skin
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... - 10% SLE or RA ... reticularis & skin ... (e.g. systemic lupus ... classification #rheumatology
Seronegative Inflammatory Arthritis - Differential Diagnosis • Seronegative Rheumatoid Arthritis • Infectious Arthritis: Viral, Bacterial,
Disease: Systemic Lupus ... Erythematous, Systemic Vasculitis ... Systemic Sclerosis, Sjogren's ... Undifferentiated UCSD ... Differential #Diagnosis #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Hypersensitivity vasculitis ... gangrenosum • IBD • RA ... Antiphospholipid-antibody syndrome • Vasculitis ... lesions • Discoid lupus ... differential #diagnosis #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Scleritis - RA ... Lyme disease, Vasculitis ... enlargement - Sjögren's ... Scleroderma Thickened skin ... differential #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(15%) Skin (85% ... Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... such as systemic lupus ... purpura: strong sign ... Serologies for Cryoglobulins ... differential #diagnosis #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Infection - Vasculitis ... - Autoimmune Vasculitis ... (lupus, RA, Sjogren's ... immunoglobulins & cryoglobulins ... • Skin biopsy
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... dermatomyositis, Sjogren ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin ... Erythematosus #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... Arthralgia and Arthritis ... #Syndrome #Rheumatology
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