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diagnosis symptoms differential classification erythematosus joint pain sle systemic arthritis behcet conditions cryoglobulinemia cryoglobulins dermatology disease extrarticular pathophysiology primary rashes
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
like rheumatoid arthritis ... (RA) or systemic ... lupus erythematosus ... (SLE) Signs / ... Xeroderma (Dry skin
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Scleritis - RA ... Lyme disease, Vasculitis ... enlargement - Sjögren's ... Scleroderma Thickened skin ... differential #diagnosis #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
gangrenosum • IBD • RA ... Antiphospholipid-antibody syndrome ... • Vasculitis ... lesions • Discoid lupus ... differential #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(15%) Skin (85% ... Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... Demyelinating syndromes ... erythematosus #signs
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... - 10% SLE or RA ... (e.g. systemic lupus ... , Sjögren's syndrome ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... • Cogan Syndrome ... such as systemic lupus ... purpura: strong sign ... differential #diagnosis #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... response to local skin ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... dermatomyositis, Sjogren ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin ... Erythematosus #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA ... Arthralgia and Arthritis ... #Syndrome #Rheumatology ... #Diagnosis #Management
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
Complications of DMARDs • Skin ... Vascular: Rheumatoid vasculitis ... Thrombocytosis, Felty's syndrome ... #RA #Signs #Symptoms ... #diagnosis #rheumatology
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