11 results
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
Cell (Temporal) Arteritis ... expression - Age: GCA ... skin lesions ... #Pathophysiology ... #Symptoms #Vasculitis
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Hypersensitivity vasculitis ... gangrenosum • IBD • RA ... Sarcoidosis • GPA ... lesions • Discoid lupus ... differential #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
and branches • GCA ... such as systemic lupus ... Presentation - Systemic Symptoms ... purpura: strong sign ... differential #diagnosis #rheumatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
like rheumatoid arthritis ... (RA) or systemic ... lupus erythematosus ... Xeroderma (Dry skin ... Sjogrens #Syndrome #Pathophysiology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... erythematosus #signs ... #rheumatology
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... manifestations Skin ... blood vessels (vasculitis ... #pathophysiology ... #signs #symptoms
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
arteritis (GCA) ... systemic sx + signs ... required due to skip ... them, but urgent rheumatology ... #Signs #Symptoms
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... Elevated ESR and CRP GCA ... develop in pts with GCA ... • Progressive symptoms ... Differential #Diagnosis #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... - 10% SLE or RA ... reticularis & skin ... (e.g. systemic lupus ... classification #rheumatology
Rheumatoid Arthritis - Signs and Symptoms
 • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans
 • Pulmonary:
- Signs and Symptoms ... Complications of DMARDs • Skin ... Vascular: Rheumatoid vasculitis ... #RA #Signs #Symptoms ... #diagnosis #rheumatology