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ana patterns testing antibody cytoplasmic disease signs symptoms syndrome treatment workup antibodies arteritis arthritis bcnie behcet bloodculture cerebritis cns endocarditis
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... body-like: - Neurologic ... ARUPLabs #ANA #Antinuclear ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... Kumfer @AnnKumfer #Antinuclear ... ANA #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... body-like: • Neurologic ... ARUPLabs #ANA #Antinuclear ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... #CNS #neurology ... #rheumatology # ... #management #treatment
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... ) - Antinuclear ... (to support a diagnosis ... ANA and RF (if clinical ... #testing #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... Behcet disease) Differential ... Oral aphthae : SLE ... #management #signs ... #symptoms #rheumatology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
rheumatoid arthritis, SLE ... life-threatening Differential ... myasthenia Diagnosis ... Myasthenia #Gravis #diagnosis ... #management #neurology
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
antimicrobials, clinical ... BCNIE Diagnostic ... See charts - ... Assays for antinuclear ... #differential #
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... Evaluate for NMO, SLE ... Disorders: - SLE ... #management #neurology ... #differential
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... salivary ducts Clinical ... phenomenon (16%) MSK ... #Diagnosis #Management
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