83 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... heliotrope rash, Shaw ... holster sign, and Gottron's ... triad of ILD, myositis ... #Autoimmune #Myositis
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Dermatomyositis Symptoms: • Gottron ... rash (Gottron papules ... and Gottron sign ... ) • Shawl sign
Dermatomyositis
A middle-aged man describes progressive difficulty combing his hair and rising from a seated position over
heliotrope rash, 2) shawl ... sign, and 3) Gottron's ... HeliotropeRash #Gottrons
Cutaneous and Systemic Findings in Dermatomyositis
Cutaneous Findings:
 - Heliotrope sign and edema
 - Nail-fold changes
 -
V-neck sign or shawl ... sign - Gottron's ... sign - Gottron's
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
periorbital heliotrope, shawl ... Necrotizing Autoimmune Myositis ... Inclusion Body Myositis
Dermatomyositis with heliotrope rash, shawl sign, and Gottron's papules

A middle-aged man describes progressive difficulty combing his
heliotrope rash, shawl ... sign, and Gottron's ... heliotrope rash, 2) shawl ... sign, and 3) Gottron's ... heliotrope #skinrash #shawl
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Myositis and Myopathies ... Inclusion body myositis
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... Inclusion Body Myositis ... , +Anti-dsDNA, Myositis ... BostonChiefs #Myositis
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Inclusion Body Myositis ... MithuRheum #Myositis
Gottron's Papules in Dermatomyositis

Another classic clue is Gottron's papules which are small grouped flat topped papules
Gottron's Papules ... classic clue is Gottron's ... RashDecisionz #Gottrons