10 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
loop of Henle Gitelman ... Syndrome: Distal ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
heparin Acute Phosphate ... intake, Phosphate ... Rhabdomyolysis, Tumor lysis syndrome ... Transcellular Shift ... #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypophosphatemia - Differential Diagnosis Algorithm
 • Decreased intake/absorption: Starvation, Alcoholism, Malabsorption, Phosphate binder use
 • Redistribution/
Malabsorption, Phosphate ... Redistribution/ Shift ... ), Hungry bone syndrome ... Algorithm #causes #nephrology ... #phosphate
Hypophosphatemia - Differential Diagnosis Algorithm
Appropriately Low Kidney Phosphate Excretion:
 • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Diarrhea, Antacids, Phosphate ... Transcellular Shift ... : Refeeding Syndrome ... Tumor Genesis Syndrome ... Diagnosis #Algorithm #nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
Fractional Excretion of Phosphate ... Transcellular Shift ... Tumor genesis syndrome ... Framework #Workup #phosphate ... #nephrology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
creatinine) • Cell shift ... Aldosterone: Cushing syndrome ... excess, Liddle syndrome ... , Gitelman syndrome ... algorithm #diagnosis #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... cotransporter • Gitelman's ... Pseudo Bartter-Gitelman ... #nephrology #management ... #pathophysiology
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Intercellular Shift ... Transcellular Shift ... Increased Urate, Phosphate ... Tumor Lysis Syndrome ... IntercellularShift #Nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts ... diuresis, Bartter's syndrome ... diuretic use), Gitelman's ... syndrome (mimics ... differential #diagnosis #nephrology