22 results
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor ... (TLS) and Treatment ... 8.0 mg/dL • Potassium ... hydroxide • Hyperkalemia ... #TLS #diagnosis
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... Spontaneous if high ... hydration - Hyperkalemia ... unless worrisome EKG ... #TLS #diagnosis
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... ) occur in high ... with Ca only if EKG ... #Lysis #Syndrome ... #TLS #oncology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Diagnosis Algorithm ... • HTN, High Aldosterone ... Renin secreting tumor ... Algorithm #causes #potassium
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... creatinine) • Cell shift ... Renin secreting tumor ... #hypokalemia ... differential #algorithm #diagnosis
Hyperkalemia - Management Algorithm
 • IV calcium
 • IV insulin and glucose and/or salbutamolt
 • Consider
and ECG changes ... blocks, QRS axis shift ... #potassium #high ... #diagnosis #management ... #algorithm #treatment
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... Diagnosis Algorithm ... Renin-secreting tumor ... #Hypokalemia # ... #causes #low #potassium
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... Transfusion reaction - Tumor ... lysis syndrome
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... ≥ 8 mg/dL • Potassium ... of the above Treatment ... of Clinical TLS ... Syndrome #diagnosis
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... Transfusion reaction - Tumor ... lysis syndrome