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diagnosis management causes differential signs nephrology oncology rhabdomyolysis treatment tumor tumorlysis uricacid acutekidneyinjury algorithm bulimianervosa cairoandbishop complications cushings encephalopathy endocrinology
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... • Hyperkalemia ... #TLS #Pathophysiology
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... Calcium ≤ 7.0 mg/dL Clinical ... hydroxide • Hyperkalemia ... #TumorLysis #Syndrome
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia ... hyperphosphatemia, #hypocalcemia ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... Syndrome: • Pathophysiology ... hydration - Hyperkalemia ... unless worrisome EKG ... #Syndrome #TLS
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... 6L/day) • For hyperkalemia ... with Ca only if EKG ... otherwise treat with "hyperkalemia ... #Syndrome #TLS
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... Intercellular Shift ... (e.g. ... Tumor Lysis Syndrome ... • Digoxin #Hyperkalemia
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
HIV, Influenza, TSS ... Dermatomyositis Clinical ... • LDH ↑ • Hyperkalemia ... Shift of extracellular ... Dialysis for severe hyperkalemia
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
iniury, Compartment syndrome ... HIV, Influenza, TSS ... Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Dialysis for severe hyperkalemia
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... hyperphosphatemia, hypercalcemia ... renal failure Clinical ... of diagnosis (e.g ... : (distinct symptoms
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
brain PRES Clinical ... Blood transfusion, Hypercalcemia ... Etiology: • Pathophysiology ... Neurological symptoms ... • EEG: With persistent
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