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diagnosis management differential causes treatment nephrology erythematosus lupus rheumatology syndrome systemic algorithm blood cerebritis cns druginduced hepatology hepatorenal hrs leukostasis
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC ... shift of K (Succinylcholine ... differential #diagnosis #pathophysiology ... #pharmacology #potassium
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... Dialysis Serum potassium ... and ECG changes ... blocks, QRS axis shift ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Intracellular Shift ... insufficiency/Failure • SLE ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Intracellular Shift ... insufficiency/Failure • SLE ... #high #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia ... levels > 8mg/dL See
Hyperkalemia Management Pseudohyperkalemia: 1. Hemolyzed sample 2. Blood drawn from a site/line where potassium or TPN is
Hyperkalemia Management ... site/line where potassium ... minutes-hour) -Shift ... @AnnKumfer #Hyperkalemia ... #high
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... Induction Rx: high-dose ... Erythematosus #SLE
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... immature blasts and high ... hydration - Hyperkalemia ... unless worrisome EKG ... diagnosis #management #hematology
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
extracellular shift ... erythematosus (SLE ... Tubulointerstitial diseases: SLE ... Differential #Diagnosis #High ... #Potassium #Classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... complements and a high ... Skin Disease Classification ... . hematologic) ... vein thrombosis Hematologic
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