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diagnosis management treatment alkaline blood differential druginduced hepatology hyophosphatasia k leukostasis lysis nephrology pharmacology phosphatase product reactions syndrome tls transfusions
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC ... shift of K (Succinylcholine ... differential #diagnosis #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
in 1923 Low ALP ... fractures of feet, thigh ... collection with EDTA Pathophysiology ... , ↓ALP → Low ... Hyperlipidemia - Hypercalcemia
Hyperkalemia Management Pseudohyperkalemia: 1. Hemolyzed sample 2. Blood drawn from a site/line where potassium or TPN is
Hyperkalemia Management ... site/line where potassium ... minutes-hour) -Shift ... or dialysis • SLOW ... #high
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... , Elevated Cr, Low ... hydration - Hyperkalemia ... unless worrisome EKG ... diagnosis #management #hematology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... heparinized tube) • ECG ... acidosis) • Low ... NOT hypertonic Amp ... Management #Treatment #potassium
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
High mortality. ... Hypocalcemia, Hyperkalemia ... products contain potassium ... Hypothermia: Due to low ... diagnosis #management #hematology
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