25 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC ... shift of K (Succinylcholine ... differential #diagnosis #pathophysiology ... #pharmacology #
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
New Potassium-Binding ... #Potassium #Binding ... KBinders #Kayexelate #Comparison ... #Table #Pharmacology ... #Patiromer #HyperKalemia
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... patients sensitive to high ... aspiration #Potassium #Binding ... medications #pharmacology ... #table #comparison
Hyperkalemia - Management Algorithm
 • IV calcium
 • IV insulin and glucose and/or salbutamolt
 • Consider
Hyperkalemia - Management ... potassium and ECG ... blocks, QRS axis shift ... , asystole #hyperkalemia ... #potassium #high
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
S - Shock H - Hyperkalemia ... Typical ECG ... proportion to other findings ... of hyperkalemia ... diagnosis #management #pathophysiology
Osborn waves - positive deflections at the J point (negative in aVR and V1) with a
electrocardiogram finding ... in people with high ... hypercalcemia, ... This EKG was recorded ... Electrocardiogram #ECG
Vasopressors Table 
Rough properties by Target Receptor, Heart Rate/Inotropy, Systemic Vascular Resistance, Cardiac Output, Blood Pressure,
Dobutamine 2-20 mcg ... - Dopamine, high ... 10-20 mcg/kg/min ... Properties #Table #Pharmacology ... Effect #Management #Comparison
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... works by directly binding ... - Hyperkalemia ( ... high potassium levels
Modified penicillin binding proteins as mechanism of resistance to antibiotics.
Penicillin Binding Proteins (Transpeptidases) cross link peptidoglycan
Modified penicillin binding ... Penicillin Binding ... the process by binding ... . high dose amox ... Proteins #AMR #PBP #pharmacology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... anticoagulant (e.g ... anticoagulant (e.g ... inhibits factor Xa by binding ... #Pharmacology #Pathophysiology