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diagnosis management treatment medications algorithm binders binding cardiology crystalloids differential digoxin druginduced effects foamed lactated lr normal ns physiology ringers
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC ... shift of K (Succinylcholine ... differential #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... Dialysis Serum potassium ... and ECG changes ... blocks, QRS axis shift ... #potassium #high
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... patients sensitive to high ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... - Hyperkalemia ( ... high potassium levels ... #Pathophysiology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
130 mEq/L • Potassium ... Is Dangerous in Hyperkalemia ... transcellular shift ... densa receives high ... #pharmacology #
Hyperkalemia Management Pseudohyperkalemia: 1. Hemolyzed sample 2. Blood drawn from a site/line where potassium or TPN is
Hyperkalemia Management ... site/line where potassium ... minutes-hour) -Shift ... @AnnKumfer #Hyperkalemia ... #high
The crusade against “Ab”Normal Saline continues. This is a non-physiologic fluid that can harm our
we introduce a high ... causes Hyperkalemia ... The high CL- content ... #foamed #criticalcare ... diagnosis #treatment #pharmacology
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