13 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC shift ... MunerMohamed1 #hyperkalemia ... differential #diagnosis #pathophysiology ... #pharmacology #
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... Transcellular Shift ... Refeeding Syndrome #Hypokalemia ... potassium #low #pathophysiology
Benign Adrenal Mass - Differential Diagnosis Algorithm
Hyperplasia - Often Bilateral
 • Congenital Adrenal Hyperplasia
 • ACTH
Hypertension +/- Hypokalemia ... • Other #AdrenalMass ... Diagnosis #Algorithm #Endocrinology
Considerations for Crystalloids - 0.9% NS vs LR vs Plasma-Lyte
 - Causes hyperkalemia?
 - Safe to
Plasma-Lyte - Causes hyperkalemia ... patients with hyperkalemia ... - Serum lactate ... #Crystalloids #pharmacology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
Lactated Ringers ... mEq/L • Sodium lactate ... Is Dangerous in Hyperkalemia ... transcellular shift ... NS #comparison #pharmacology
Hypophosphatemia - Differential Diagnosis Algorithm

Transcellular Shift
 • Recovery From DKA
 • Refeeding Syndrome
 • Acute Respiratory
Transcellular Shift ... Alkalosis • Hypokalemia ... Diagnosis #Algorithm #endocrinology
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
happypillsrx/ #Hyperkalemia ... #Pathophysiology ... #Pharmacology #
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
• LDH ↑ • Hyperkalemia ... /Late - Hypercalcemia ... Shift of extracellular ... Isotonic fluid/Lactated ... Dialysis for severe hyperkalemia
Malignant Adrenal Mass - Differential Diagnosis Algorithm
Suggestive of Malignancy: Inhomogenous Density, Delay in CT Contrast Washout
Hypertension +/- Hypokalemia ... Carcinoma #AdrenalMass ... Diagnosis #Algorithm #Endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
wasting crisis & hyperkalemia ... Complications: • Hyperkalemia ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology