12 results
Modified penicillin binding proteins as mechanism of resistance to antibiotics.
Penicillin Binding Proteins (Transpeptidases) cross link peptidoglycan
Modified penicillin binding ... resistance to antibiotics ... Penicillin Binding ... (e.g. high dose ... Proteins #AMR #PBP #pharmacology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... phlebotomy High ... Beta blockers • Antibiotics ... Intracellular Shift ... causes #potassium #high
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat Hyperkalemia ... patients sensitive to high ... aspiration #Potassium #Binding ... medications #pharmacology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... phlebotomy High ... Beta blockers • Antibiotics ... Intracellular Shift ... causes #potassium #high
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
Flutycosine - Antibiotics ... monotherapy due to high ... #Pharmacology #Antibiotics ... #Review #Overview
Fluoroquinolones - Antibiotics Class Overview

Mechanism: DNA Gyrase  and Topoisomerase inhibitors bactericidal 
Side effects: QT prolongation
Fluoroquinolones - Antibiotics ... High rate of c.diff ... #Pharmacology #Antibiotics ... #Review #Overview
ANTIBIOTICS WITH ANAEROBE COVERAGE - Antibiotics Class Overview
 1. Metronidazole (Flagyl)(PO and IV)
 2. Clindamycin –
ANTIBIOTICS WITH ... infections due high ... infections (due to high ... #Pharmacology #Antibiotics ... #Review #Overview
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... NSAIDs, β-blockers, Antibiotics ... offending medications (review ... Treatments: • K-Binding ... #Hyperkalemia
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... works by directly binding ... - Hyperkalemia ( ... high potassium levels ... , in states of hypokalemia
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS)

This is a very common pathway that clinicians should
Here’s a review ... this pathway, ending ... avoid harmful hyperkalemia ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology