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diagnosis differential management medications nephrology treatment evaluation high antihypertensive arb blood bloodpressure cardiology constipation contraindications druginduced hematology hfpef hypertension hypokalemia
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... Angiotensin-converting enzyme (ACE ... • Increased EC ... shift of K (Succinylcholine ... #pharmacology #potassium
Compelling and Possible Contraindications to Antihypertensive Drugs Diuretics (thiazides) - Gout - Metabolic syndrome, Glucose intolerance, Pregnancy,
(ACEI, ARB, diabetes ... ) ACE inhibitors ... Pgp-dependent drugs (e.g ... antihypertensive #medications ... contraindications #table
Constipation - Differential Diagnosis Algorithm Diet/Lifestyle • Fibre • Calories • Fluid • Exercise • Psychosocial Medications •
(e.g. ... Cation Related (e.g ... Aluminum, Calcium, Potassium ... Anticholinergic (e.g ... #Causes
Medications for the Treatment of Hyperkalemia The goals of acute treatment are to prevent potentially life-threatening cardiac
disturbances, shift ... underlying problem can ... , changes on ECG ... Figure 3 is an algorithm ... , and Table 3 summarizes
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 ACEI or ARB Initiation Hyperkalemia: - Review concurrent drugs - Moderate potassium Intake - Consider: diuretics, sodium
Hyperkalemia: ... drugs - Moderate potassium ... - Review for causes ... (e.g., diuretics ... Initiation #monitoring #algorithm
Emergent Hyperkalemia Treatment Algorithm ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
ECG changes, weakness ... injury, etc) ECG ... cardiac membrane Shift ... treatment Remove potassium ... offending agent (ACE-I
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
: • CKD • Poorly ... • NSAIDs • ACE ... Intracellular Shift ... Medications 2. ... differential #diagnosis #causes
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
: • CKD • Poorly ... • NSAIDs • ACE ... Intracellular Shift ... Medications 2. ... differential #diagnosis #causes
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
: K+, ACEi/ARBs, ... heparinized tube) • ECG ... only if no clear cause ... Elimination (see Table ... Management #Treatment #potassium
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
risk factors (eg ... hypertension (eg ... hypertension (eg ... Vasculitis • Endocrinologic ... Differential #Diagnosis #indications
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