34 results
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... 6L/day) • For hyperkalemia ... with Ca only if EKG ... #Syndrome #TLS
Emergency Management of Hyperkalemia in Adults
Assess Patient - Airway Breathing Circulation Disability Exposure (ABCDE) Approach
 •
Management of Hyperkalemia ... clinical scenario, ECG ... Gluconate IV Shift ... Consider cause of hyperkalaemia ... recurrence #Hyperkalemia
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... Low calcium • Treatment ... hydration - Hyperkalemia ... treatment (no calcium ... unless worrisome EKG
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... Intercellular Shift ... Transcellular Shift ... (e.g. ... Tumor Lysis Syndrome
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... Intracellular Shift ... release due to cell lysis ... reaction - Tumor lysis ... syndrome - Rhabdomyolysis
Compelling and Possible Contraindications to Antihypertensive Drugs
Diuretics (thiazides)
 - Gout
 - Metabolic syndrome, Glucose intolerance, Pregnancy,
- Metabolic syndrome ... , Hypokalemia, Erectile ... Pgp-dependent drugs (e.g ... - Metabolic syndrome ... contraindications #table
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... Intracellular Shift ... release due to cell lysis ... reaction - Tumor lysis ... syndrome - Rhabdomyolysis
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... and Treatment of ... hydroxide • Hyperkalemia ... #TumorLysis #Syndrome
Hypermagnesemia - Etiologies by Mechanism
Renal Failure 
Excessive Mg Administration 
 - Massive PO intake
IV Mg infusion (e.g ... Mechanisms - Tumor lysis ... syndrome Dr. ... High #Magnesium #Table
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
BRASH Syndrome ... Typical ECG ... ) BRASH Treatment ... • Aggressive treatment ... DrEricStrong #BRASH #Syndrome