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management potassium nephrology differential hematology algorithm binding causes coagulation deficiencies deficiency diuresis diuretics dosing druginduced drugs effects excretion high hivaids
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
also binds magnesium ... nonspecifically binds ... #medications #pharmacology ... #table #comparison ... #binders
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... of K (Succinylcholine ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... Management of Hyperkalemia ... #Management #Hyperkalemia ... #treatment #pharmacology ... #table #comparison
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
depletion • Consider K+ ... binder • Consider ... blocks, QRS axis shift ... potassium #high #diagnosis ... management #algorithm #treatment
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... Etiology: • Medications ... Elimination (see Table ... STOP offending medications ... #Diagnosis #Management
Medications for the Treatment of Hyperkalemia The goals of acute treatment are to prevent potentially life-threatening cardiac
Medications for ... disturbances, shift ... , changes on ECG ... , and Table 3 summarizes ... medications used
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 Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Acquired: • Vitamin K ... Malabsorption (e.g ... Anticoagulant Medications ... Deficiencies #Summary #table ... #comparison #diagnosis
PDE5 inhibitors are usually the drugs of first choice for erectile dysfunction. PDE5 inhibitors enhance an erection that is
with caution - e.g ... #pharmacology #comparison ... #treatment #medications ... dosing #drugs #table
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
Saline (NS) - Comparison ... trial • Minimal K ... Is Dangerous in Hyperkalemia ... transcellular shift ... #pharmacology #
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Differential Diagnosis ... Shift of extracellular ... fluid/Lactated ringers ... per day until stable ... #Differential #Diagnosis
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