36 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Puncture, EEG Treatment ... Induction Rx: high-dose ... CNS #neurology #rheumatology ... diagnosis #management #treatment
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... severe disease Treatment ... Severe disease- high ... #Systemic #Lupus ... Summary #diagnosis #rheumatology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... creatinine) • Cell shift ... mmol creatinine) High ... Low-normal EABV, High ... #hypokalemia
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... phlebotomy High ... Intracellular Shift ... - Tumor lysis syndrome ... causes #potassium #high
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
associated with hypokalemia ... hypomagnesemia Hypokalemia ... - Shift from extracellular ... - Insulin (high ... renal Fanconi syndrome
Hyperkalemia - Management Algorithm
 • IV calcium
 • IV insulin and glucose and/or salbutamolt
 • Consider
Hyperkalemia - Management ... blocks, QRS axis shift ... , asystole #hyperkalemia ... #potassium #high ... management #algorithm #treatment
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... phlebotomy High ... Intracellular Shift ... - Tumor lysis syndrome ... causes #potassium #high
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... cytotoxic therapies in high-burden ... ) occur in high ... malignancies Treatments ... #Tumor #Lysis #Syndrome
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... organ damage • Treatment ... Spontaneous if high ... hydration - Hyperkalemia ... diagnosis #management #hematology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Compartment syndrome ... Neuroleptic malignant syndrome ... or compartment syndrome ... Shift of extracellular ... Treatment of underlying