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diagnosis treatment hyperkalemia differential nephrology algorithm causes comparison table criticalcare pathophysiology dosing drugs renal agents anesthesia atopic binders cardiology coccidioides
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift ... Thyrotoxicosis Medications ... Transcellular shifts ... nephrology #low #potassium
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC shift ... Benyzlpenicillin, blood ... pathophysiology #pharmacology ... #potassium #medications
Hyperkalemia Treatment Options Stabilize cardiac membrane: • IV Calcium (peaks 5-10 minutes) Decrease potassium concentration: • IV Fluids Shift
Hyperkalemia Treatment ... • IV Fluids Shift ... peaks 1-2h) • Blood ... LouLectures #Hyperkalemia ... #management #potassium
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
patients with hypokalemia ... the basis of the potassium-to-creatinine ... creatinine) • Cell shift ... effective arterial blood ... #urine #potassium
Causes of Hyperkalemia Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
caused by excess potassium ... intake, impaired potassium ... transcellular shifts ... renal function, medication ... adapt to excess potassium
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 Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Crush injury • Blood ... Intracellular Shift ... Medications 2. ... Blood transfusion
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Crush injury • Blood ... Intracellular Shift ... Medications 2. ... Blood transfusion
Hyperkalemia: Diagnostic algorithm Decreased renal potassium excretion • Acute renal failure • Chronic renal failure • Drugs Increased
Hyperkalemia: Diagnostic ... diet • Blood ... Normal, Renin High ... hypoplasia Aldosterone high ... • Type 1 #Hyperkalemia
Medications for the Treatment of Hyperkalemia The goals of acute treatment are to prevent potentially life-threatening cardiac
Medications for ... disturbances, shift ... algorithm for the management ... Table 3 summarizes medications ... #Management #Medications
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 Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat Hyperkalemia ... patients sensitive to high ... of aspiration #Potassium ... #medications #pharmacology
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